КАТТАЛАРДА ЎСИШ ГОРМОНИ ЕТИШМОВЧИЛИГИНИНГ СУЯК ТУЗИЛИШИ ВА МЕТАБОЛИЗМИГА ТАЬСИРИ
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Соматотроп гормон, Ўсиш гормони етишмовчилиги (ЎГЕ), ИЎО – 1, ДЕХА, КЎГЕ ҳаёт сифати сўровномаси (QoL-AGHDA – Quality of Life Adult Growth Hormone Deficiency Assessment)Abstrak
Ўсиш гормони етишмовчилиги – бу катталарда организмнинг нормал ишлаши учун зарур бўлган ўсиш гормонининг етарли миқдорда ишлаб чиқарилмайдиган холатидир. Бу гормон ўсишни, суяк шаклланишини ва умумий метаболизмни тартибга солишда асосий рол ўйнайди. Шунга қарамай Ўсиш гормони етишмовчилиги кўпинча болалик давридаги ривожланиш билан боғлиқ бўлсада, у катталарда ҳам кузатилиши мумкин. Бу эса жиддий тиббий муаммодир. КЎГЕ Болалик даврида бошланган (CO-AGHD) ёки катта ёш даврида бошланган деб тавсифланиб (AO-AGHD), бунда йилига мос равишда 100000 тадан 2 та ёки 10000 тадан 1 та ҳолат кузатилиши мумкин
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Ван ден Белд А.В., Кауфман Дж.М., Цилликенс М.К., Ламбертс С.Дж., Иган Дж.М., ван дер Лели А.Дж. Физиология эндокринной системы с возрастом. Lancet Diabetes Endocrinol (2018) 6: 647-58. 10.1016/S2213-8587(18)30026-3 [Бесплатная статья PMC] [PubMed] [Перекрестная ссылка] [Google Scholar]
Hazem, A., Elamin, M. B., Bancos, I., Malaga, G., Prutsky, G., Domecq, J. P., et al. (2012). Body composition and quality of life in adults treated with GH therapy: a systematic review and meta-analysis. Eur. J. Endocrinol. 166, 13–20. doi:10.1530.EJE-11-0558
Bengtsson B.-A., Edin S., Lonn L. et al //J. clin. Endocr. 1993,Vol. 76, P. 309-317. https://doi.org/10.14341/probl12151.
Melmed S. Idiopathic adult growth hormone deficiency. J Clin Endocrinol Metab 2013; 98:2187 – 97.
Fleseriu M, Hashim IA, Karavitaki N, et al. J Clin Endocrinol Metab. 2018. DOI: 10.1210/jc.2016-2118.
Arnika Wydra, Izabekka Czasjka – Oraniec, Jakub Wydra, Wojciech Zgliczynski The influence of growth hormone deficiency on bone health and metabolism et al. J Reumatologia2023;61, 4 : p: 239 – 247.
Andrzej Lewiński12, Joanna Smyczyńska2, Renata Stawerska2, Maciej Hilczer3, Magdalena Stasiak2, Tomasz Bednarczuk4, Marek Bolanowski5, Roman Junik6, Marek Ruchała7, Anhelli Syrenicz8, Mieczysław Walczak9, Wojciech Zgliczyński10, Małgorzata Karbownik-Lewińska211. DOI: 10.5603/EP.a2018.0054 (https://doi.org/10.5603/EP.a2018.0054) Pubmed: 30117531 (https://www.ncbi.nlm.nih.gov/pubmed/30117531). Endokrynol Pol 2018; 69 (5):468-524.
Tritos NA, Hamrahian AH, King D, Greenspan SL, Cook DM, Jonsson PJ, Wajnrajch MP, Koltowska-Haggstrom M, Biller BM. A longer interval without GH replacement and female gender are associated with lower bone mineral density in adults with childhood-onset GH deficiency: a KIMS database analysis. European Journal of Endocrinology 2012.167 343–351.
Kassem M, Blum W, Ristelli J, Mosekilde L, Eriksen EF 1993 Growth hormone stimulates proliferation and differentiation of normal human osteoblast-like cells in vitro. Calcif Tissue Int 52:222–226.
Ashraf Mohamed Assistant prof. of Internal Medicine, Faculty of Medicine, Mansoura University, Egypt Correspondence to Ashraf Mohamed, MD, Assistant prof. of Internal Medicine, Faculty of Medicine, Mansoura University, Mansoura, Dakahlyiah, Serum β-CrossLaps as a predictor for osteoporosis in postmenopausal women with early diabetic nephropathy The Egyptian Journal of Internal Medicine 2019, 31:52–5
Tritos NA, Klibanski A. Effects of Growth Hormone on Bone. Prog Mol Biol Transl Sci 2016; 138: 193–211, DOI:10.1016/bs.pmbts.2015.10.008.
Giustina A, Mazziotti G, Canalis E. Growth hormone, insulin-like growth factors, and the skeleton. Endocr Rev 2008; 29:535–559, DOI: 10.1210/er.2007 – 0036.
Hitz MF, Jensen JE, Eskildsen PC. Bone mineral density in patients with growth hormone deficiency: does a gender difference exist? Clin Endocrinol (Oxf) 2006; 65: 783–791, DOI:10.1111/j.1365-2265.2006.02667.x
Mazziotti G, Lania AG, Canalis E. Skeletal disorders associated with the growth hormone-insulin-like growth factor 1axis. Nat Rev Endocrinol 2022; 18: 353–365, DOI: 10.1038/ s41574-022-00649-8.
C. Ohlsson, D. Mellstrom, D. Carlzon, E. Orwoll, O. Ljunggren, M.K. Karlsson, L. Vandenput, Older men with low serum IGF-1 have an increased risk of incident fractures: the MrOS Sweden study. J. Bone Miner. Res. 26, 865–872 (2011).
Yuen KCJ, Biller BMK, Radovick S, et al. American Association of Clinical Endocrinologists and American College of Endocrinology Guidelines For Management of Growth Hormone Deficiency in Adults And Patients Transitioning From Pediatric to Adult Care. Endocr Pract 2019; 25: 1191–1232, DOI: 10.4158/ GL-2019-0405.
Molitch ME, Clemmons DR, Malozowski S, et al. Endocrine Society. Evaluation and treatment of adult growth hormone deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2011; 96: 1587–1609, DOI: 10.1210/ jc.2011-0179.
Giustina A, Mazziotti G, Canalis E. Growth hormone, insulin-like growth factors, and the skeleton. Endocr Rev 2008; 29: 535–559, DOI: 10.1210/er.2007-0036.
Varlamov E, McCartney S, Fleseriu M. Growth hormone deficiency and replacement effect on adult bone mass: A clinical update. Curr Opin Endocr Metabol 2018; 3: 7–20.
Holmes SJ, Economou G, Whitehouse RW, et al. Reduced bone mineral density in patients with adult onset growth hormone deficiency. J Clin Endocrinol Metab 1994; 78: 669–674, DOI: 10.1210/jcem.78.3.8126140.
Ho KK; 2007 GH Deficiency Consensus Workshop Participants. Consensus guidelines for the diagnosis and treatment of adults with GH deficiency II: a statement of the GH Research Society in association with the European Society for Pediatric Endocrinology, Lawson Wilkins Society, European Society of Endocrinology, Japan Endocrine Society, and Endocrine Society of Australia. Eur J Endocrinol 2007; 157: 695– 700, DOI: 10.1530/EJE-07-0631.
Baroncelli GI, Bertelloni S, Ceccarelli C, Saggese G. Measurement of volumetric bone mineral density accurately determines degree of lumbar undermineralization in children with growth hormone deficiency. J Clin Endocrinol Metab 1998; 83: 3150–3154, DOI: 10.1210/jcem.83.9.5072.
Muydinov Muhammadzoir Zafarjon o'g'li. (2024). SHOYIM BO'TAYEV HIKOYALARIDA XARAKTERLAR TASVIRI. Konferensiyalar | Konferentsiyalar , 1 (4), 263–268.
Muydinov , MZ o'g'li. (2023). ANVAR OBIDJON ASARLARINING NASRIY POETIKASI. OLTIN MIYA , 1 (12), 47-55.
Muydinov , MZ o'g'li. (2023). ANVAR OBIDJONNING IJOD LABARATORIYASIING SHAKLLANISHIGA BIR NAZAR. OLTIN MIYA , 1 (10), 120-125.
Zafarjon o'g'li M. M. ANVAR OBIDJON ASARLARINING NASRIY POETIKASI. – 2023.
Zafarjon o'g'li, Muydinov Muhammadzoir. "ANVAR OBIDJON ASARLARINING NASRIY POETIKASI." (2023).
Zafarjon o'g'li, M. M. (2023). ANVAR OBIDJON ASARLARINING NASRIY POETIKASI.
Zafarjon o‘g‘li, Muydinov Muhammadzoir. "ANVAR OBIDJONNING IJOD LABARATORIYASINING SHAKLLANISHIGA BIR NAZAR." ISSN 2181-4120 VOLUME 1, ISSUE 10 APRIL 2023 (2023): 120.
Zafarjon o‘g‘li, M. M. (2023). ANVAR OBIDJONNING IJOD LABARATORIYASINING SHAKLLANISHIGA BIR NAZAR. ISSN 2181-4120 VOLUME 1, ISSUE 10 APRIL 2023, 120.
Zafarjon o‘g‘li M. M. ANVAR OBIDJONNING IJOD LABARATORIYASINING SHAKLLANISHIGA BIR NAZAR //ISSN 2181-4120 VOLUME 1, ISSUE 10 APRIL 2023. – 2023. – С. 120.
